SrasV1, Main, Exploration, bibRecord, 001E24

Sequential biogenesis of host cell membrane rearrangements induced by hepatitis C virus infection

Identifieur interne : 001E24 ( Main/Exploration ); précédent : 001E23; suivant : 001E25

Sequential biogenesis of host cell membrane rearrangements induced by hepatitis C virus infection

Auteurs : Pauline Ferraris [France] ; Elodie Beaumont [France] ; Rustem Uzbekov [France] ; Denys Brand [France] ; Julien Gaillard [France] ; Emmanuelle Blanchard [France] ; Philippe Roingeard [France]

Source :

Cellular and Molecular Life Sciences [ 1420-682X ] ; 2013-04-01.

RBID : ISTEX:FB88C65A15C64A2810A3E9A2DC597CEB63602FC0

English descriptors

KwdEn :
- 3D reconstruction, Electron microscopy, HCV, Host cell membranes, Membranous web.

Abstract

Abstract: Like most positive-strand RNA viruses, hepatitis C virus (HCV) forms a membrane-associated replication complex consisting of replicating RNA, viral and host proteins anchored to altered cell membranes. We used a combination of qualitative and quantitative electron microscopy (EM), immuno-EM, and the 3D reconstruction of serial EM sections to analyze the host cell membrane alterations induced by HCV. Three different types of membrane alteration were observed: vesicles in clusters (ViCs), contiguous vesicles (CVs), and double-membrane vesicles (DMVs). The main ultrastructural change observed early in infection was the formation of a network of CVs surrounding the lipid droplets. Later stages in the infectious cycle were characterized by a large increase in the number of DMVs, which may be derived from the CVs. These DMVs are thought to constitute the membranous structures harboring the viral replication complexes in which viral replication is firmly and permanently established and to protect the virus against double-stranded RNA-triggered host antiviral responses.

Url:

https://api.istex.fr/ark:/67375/VQC-5X7HMXKM-B/fulltext.pdf

DOI: 10.1007/s00018-012-1213-0

Affiliations:

Links toward previous steps (curation, corpus...)

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to stream Main, to step Merge: 001E48
to stream Main, to step Curation: 001E24

Le document en format XML

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<front><div type="abstract" xml:lang="en">Abstract: Like most positive-strand RNA viruses, hepatitis C virus (HCV) forms a membrane-associated replication complex consisting of replicating RNA, viral and host proteins anchored to altered cell membranes. We used a combination of qualitative and quantitative electron microscopy (EM), immuno-EM, and the 3D reconstruction of serial EM sections to analyze the host cell membrane alterations induced by HCV. Three different types of membrane alteration were observed: vesicles in clusters (ViCs), contiguous vesicles (CVs), and double-membrane vesicles (DMVs). The main ultrastructural change observed early in infection was the formation of a network of CVs surrounding the lipid droplets. Later stages in the infectious cycle were characterized by a large increase in the number of DMVs, which may be derived from the CVs. These DMVs are thought to constitute the membranous structures harboring the viral replication complexes in which viral replication is firmly and permanently established and to protect the virus against double-stranded RNA-triggered host antiviral responses.</div>
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Sequential biogenesis of host cell membrane rearrangements induced by hepatitis C virus infection

Sequential biogenesis of host cell membrane rearrangements induced by hepatitis C virus infection

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri